Lipoate-Protein Ligase A (LplA)
Protein Data Bank ID: 2AAI
Protein Name: Lipoate-Protein Ligase A
Organism: Escherichia coli
Recently two students who used to work in our lab asked me to draw a special protein. Lipoate-protein ligase A (LplA) is an enzyme which catalyzes the attachment of lipoic acid to specific enzymes. This allows lipoic acid to act as a coenzyme primarily in oxidative decarboxylation reactions. Recently, this ability of LplA was used to label proteins with fluorescent tags [*].
And here are the outcomes:
One possible memory aid could go as follows: Like the Pakul helps to identify a Pashtun, LplA can help to identify proteins by labeling them.
Just turn the protein image through 180° and you will see a completely different motif which has absolutely no connection to the previous one.
Here the fatty tart might remind us of the fact that LplA is involved in the attachment of lipoic acid which in its turn is involved in the lipid metabolism.