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July 31, 2013 / May K.

CDK5-P25 Complex


Dear readers of my blog,

I have to apologize for not being active for a while! I have received many great protein orders and little by little I am working on their realization. But unfortunately, I have a quite tough time this year as the final countdown of my PhD began. I will make up for the missing posts as soon as I can. Thank you for your understanding and patience! Here is a small reward:

Protein Data Bank ID: 1H4L
Protein Name: CDK5-P25 Complex
Organism: Homo sapiens
Title of Drawing: “Baby Dragon Playing with a Toy House“

Cyclin-dependent kinase 5 (CDK5) is an enzyme which triggers the phosphorylation of a key protein of the reelin signaling pathway. Via this pathway CDK5 is involved in neuronal migration and positioning. For its activation CDK5 needs a cofactor, p35 (a fragment of p35 called p25 is shown in the bottom part of this drawing). Recent studies have shown that CDK5 is required already early on during brain development [1].

Similar to ‘playing games’, CDK5 is necessary for a proper development of children’s brain. This baby dragon playing with his toy house illustrates these connections.

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8 Comments

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  1. Naomi / Aug 2 2013 6:19 am

    Oh, that is so cute! I think one of my lecturers studies this protein. Good to see you’re back!

  2. PractitioNERD / Aug 14 2013 8:45 pm

    Don’t worry; we can handle a hiatus since you were focusing on the time-consuming responsibility of obtaining a Ph.D. Congrats, by the way! 🙂 I remember how time-consuming it was when I was just getting my MASTERS; so I’m sure this was WAY MORE intense! 🙂 We understand, and WELCOME BACK! 🙂

    • May K. / Oct 28 2013 8:44 am

      Oh, it’s still too early for congratulations as I’m not finished yet. That was rather a notification that I will be absent for some more time… but still thank you for the warm words, and congrats on your masters!:))

  3. A Hopeful Doc / Oct 27 2013 9:48 pm

    Wow, you have such a wonderful concept. I just stumbled onto your blog with these beautiful renditions of molecules which I didn’t particularly care for last year… your art would’ve inspired happier thoughts about that first semester of biochem!

    • May K. / Oct 28 2013 8:51 am

      Thank you! It really makes me happy to learn that my drawings can trigger some positive feelings for proteins!:)))

      • A Hopeful Doc / Oct 28 2013 2:36 pm

        I later showed my friends your pics as we just finished reviewing the cyclin-dependent kinase pathway–they think you’re brilliant!

  4. Emma Sarah Tennant / Mar 18 2014 11:36 am

    What a great post, thanks for sharing.

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