July 31, 2013 / May K.

CDK5-P25 Complex

Art, art and science, Biochemie, biochemistry, Biologie, Biology, brain, Enzymes, Kunst, neuroscience, Proteins, Science, Wissenschaft

Dear readers of my blog,

I have to apologize for not being active for a while! I have received many great protein orders and little by little I am working on their realization. But unfortunately, I have a quite tough time this year as the final countdown of my PhD began. I will make up for the missing posts as soon as I can. Thank you for your understanding and patience! Here is a small reward:

Protein Data Bank ID: 1H4L
Protein Name: CDK5-P25 Complex
Organism: Homo sapiens
Title of Drawing: “Baby Dragon Playing with a Toy House“

Cyclin-dependent kinase 5 (CDK5) is an enzyme which triggers the phosphorylation of a key protein of the reelin signaling pathway. Via this pathway CDK5 is involved in neuronal migration and positioning. For its activation CDK5 needs a cofactor, p35 (a fragment of p35 called p25 is shown in the bottom part of this drawing). Recent studies have shown that CDK5 is required already early on during brain development [1].

Similar to ‘playing games’, CDK5 is necessary for a proper development of children’s brain. This baby dragon playing with his toy house illustrates these connections.

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About Protein Art

In this blog I would like to share my pictures which are inspired by proteins.

Proteins are molecules essential for every living organism. Not a single cell could exist without proteins. They represent long chains composed of amino acids. These chains fold into three-dimensional structures. The 3D structure of a protein is the template for my drawings.

I vary and rotate the three-dimensional protein image by means of a special computer software until an interesting shape appears. Subsequently, I color and design the produced snapshot so that the image I saw becomes obvious to the viewer.

My goal is not only to present my drawings. I also attempt to provide my readers with some information about proteins. I prefer to do so in an informal and hopefully humorous way.

© All rights reserved by May K.

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