Integrin α2β1

Protein Data Bank ID: 1AOX
Protein Name: Integrin α2β1 I domain
Organism: Homo sapiens
Title of Drawing: “Community”

Another request from 2012, sorry for the huge delay, najas!

This scene is based on the integrin α2β1 I domain. Integrins are transmembrane proteins establishing connections between adjacent cells or between cells and the extracellular space. Integrin α2β1 can bind collagen or laminin and thereby not only ensures adhesion between the cellular skeleton and the extracellular matrix, but also can serve as a signal receiver for the cell.

The name “integrin” originates from the fact that these molecules are integral membrane proteins. Analogously to integrins incorporated into the membrane, members of religious groups such as Amish and Mennonites outlined in this drawing are highly integrated within their communities. An example to this is the warmth that has been bestowed on the sad girl by the other community members.